Sigma-Aldrich Trichostatin A Streptomyces sp

Sigma-Aldrich Calbiochem Trichostatin A Streptomyces sp., 1 mg Net Content, C17H22N2O3, Solid Form, Yellow, >=98 %, -20 deg C, Melting Point: 140 to 143 deg C, Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem, 4,6-Dimethyl-7-[ p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX, 302.37 g/mol Molecular Weight, 58880-19-6 CAS Number, HPLC Grade. A potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3Bcells. IC50 = 6 nM for HDAC1; 38 nM for HDAC4 and 8.6 nM for HDAC6A. 10 mM (500 ug/165 uL) solution of Trichostatin A, Streptomyces sp. (647926) in DMSO is also available. A potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH 3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. IC50 = 6 nM for HDAC1; 38 nM for HDAC4 and 8.6 nM for HDAC6A - SIAL (Additional S&H Or Hazmat Fees May Apply)