Miltenyi Biotec Clinimacs Cd304 (Bdca-4) Gmp Microbeads

Miltenyi Biotec In human blood and bone marrow, CD304 (BDCA-4, Neuropilin-1) is exclusively expressed on plasmacytoid dendritic cells (PDCs), which are characterized as CD11c, CD123bright, and CD303 (BDCA-2)+.1,2 PDCs represent about 0.2% of white blood cells. | They are the main producers of type 1 interferons, which strongly stimulate the differentiation of other immune cells. PDCs have a poor pino- and phagocytosis capacity and take up exogenous antigens predominantly by receptor-mediated endocytosis. 3) Apart from their immune stimulatory functions, they are also intensively discussed to be involved in tolerance induction. 4 ) | The CliniMACS® CD304 (BDCA-4) Product Line consists of murine CD304 (BDCA-4) monoclonal antibodies conjugated to superparamagnetic iron dextran particles. | One vial contains 7.5 mL sterile, non-pyrogenic solution. | The performance of the CliniMACS CD304 (BDCA-4) Product Line depends on the individual separation strategy. For information on respective capacities, refer to the CliniMACS User Manual or contact your local representative. | Please inquire about required CliniMACS System components and accessories. - MLTY (Additional S&H or Hazmat Fees May Apply)