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Cayman Protein Determination (Bca) Kit; Size- 480 Wells
Cayman Protein Determination (Bca) Kit; Size- 480 Wells; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$146.00
Your Price
$146.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-701780-480 |
MFG.PART: | 701780-480 |
UNSPSC: | 41116104 |
Manufacturer: | Cayman |
Product Description
ARS853 is an inhibitor of K-RASG12C, a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells. ARS853 binds to the inactive GDP-bound state of K-RASG12C. It decreases the level of active GTP-bound K-RAS by 95% when used at a concentration of 10 µM in K-RASG12C mutant lung cancer cells. It also decreases phosphorylation of c-RAF, ERK, and Akt. ARS853 inhibits proliferation of six lung cancer cell lines containing the K-RASG12C mutation, including H358 cells (IC50 = 2.5 µM), but does not inhibit proliferation of PC-9 cells, which contain wild-type K-RAS.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[3-[4-[2-[[4- chloro-2- hydroxy-5-(1- methylcyclo propyl)phenyl] amino]acetyl]- 1-piperazinyl] -1-azetidinyl] -2-propen- 1-one
CAS Number
1629268-00-3
Molecular Formula
C22H29ClN4O3
Formula Weight
432.9
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMSO: 50 mg/ml
λmax
211, 249 nm
SMILES
CC1(CC1)C2=C(Cl)C=C(O)C(NCC(N3CCN(C4CN(C(C=C)=O)C4)CC3)=O)=C2
InChi Code
InChI=1S/C22H29ClN4O3/c1-3-20(29)27-13-15(14-27)25-6-8-26(9-7-25)21(30)12-24-18-10-16(22(2)4-5-22)17(23)11-19(18)28/h3,10-11,15,24,28H,1,4-9,12-14H2,2H3
InChi Key
IPFOCHMOYUMURK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-701780-480 |
---|---|
Supplier Part Number | 701780-480 |
UM | EA |
UNSPSC | 41116104 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/701780m.pdf |
Temperature | 4 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |