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Cell Signaling Ob-Cadherin (16g5) Mouse mAb
Cell Signaling Ob-Cadherin (16g5) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
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$324.00
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NETA PART: | CSIG-13577S |
MFG.PART: | 13577S |
UNSPSC: | 41116113 |
Manufacturer: | Cell Signaling |
Size | 100 µl |
Reactivity | H |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 120 |
Source/Isotype | Mouse IgG1 |
Application/Dilution | {Western Blotting: 1:1000, Immunofluorescence (Immunocytochemistry): 1:3200, Flow Cytometry (Fixed/Permeabilized): 1:3200, Flow Cytometry (Live): 1:3200} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | OB-Cadherin (16G5) Mouse mAb recognizes endogenous levels of total OB-cadherin protein. |
Species Reactivity | Human |
Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein containing the extracellular cadherin domain 1 of OB-cadherin fused to maltose binding protein. |
Background | Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development (1). The classic cadherin subfamily includes N-, P-, R-, B-, and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. The cytoplasmic domain of classical cadherins interacts with β-catenin, γ-catenin (also called plakoglobin), and p120 catenin. β-catenin and γ-catenin associate with α-catenin, which links the cadherin-catenin complex to the actin cytoskeleton (1,2). While β- and γ-catenin play structural roles in the junctional complex, p120 regulates cadherin adhesive activity and trafficking (1-4). Investigators consider E-cadherin an active suppressor of invasion and growth of many epithelial cancers (1-3). Research studies indicate that cancer cells have upregulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch." N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion (3). Research studies have shown that in endothelial cells, VE-cadherin signaling, expression, and localization correlate with vascular permeability and tumor angiogenesis (5,6). Investigators have also demonstrated that expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers (7,8).OB-cadherin (CDH11) is highly expressed in osteoblastic cell lines (9). Its upregulation during differentiation in cells of the osteo-lineage and the chondro-lineage implies a specific role in bone cell differentiation and bone formation (9,10). |
SKU | CSIG-13577S |
---|---|
Supplier Part Number | 13577S |
UM | UNIT |
UNSPSC | 41116113 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |