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Cell Signaling Syndecan 1 (D4y7h) Rabbit mAb (Pe Conjugate)
Cell Signaling Syndecan 1 (D4y7h) Rabbit mAb (Pe Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$435.00
Your Price
$435.00
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| NETA PART: | CSIG-55987S |
| MFG.PART: | 55987S |
| UNSPSC: | 41116113 |
| Manufacturer: | Cell Signaling |
| Size | 100 µl (50 tests) |
| Reactivity | H |
| Sensitivity | Endogenous |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Flow Cytometry (Fixed/Permeabilized): 1:50} |
| Storage | Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze. |
| Specificity/Sensitivity | Syndecan 1 (D4Y7H) Rabbit mAb (PE Conjugate) recognizes endogenous levels of multimeric forms of syndecan 1 protein. The unconjugated antibody cross-reacts with proteins of unknown origin between 46-60 kDa in some cell lines by western blot analysis. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala294 of human syndecan 1 protein. |
| Background | Syndecans are a family of type 1 transmembrane heparan sulphate proteoglycans comprising four members in mammals (SDC-1 to -4) (1) encoded by four syndecan genes. Syndecans are involved in embryonic development, tumorigenesis, and angiogenesis (2). The extracellular domain harbors attachment sites for heparan sulfate and chondroitin sulfate chains, facilitating interaction with an array of proteins including a plethora of growth factors. In addition, the hydrophobic C-terminal intracellular domain can interact with proteins containing a PDZ domain (2). These interactions place syndecans as important integrators of membrane signaling (3). Syndecans undergo proteolytic cleavage causing the release of their extracellular domain (shedding), converting the membrane-bound proteins into soluble molecular effectors (4). |
| SKU | CSIG-55987S |
|---|---|
| Supplier Part Number | 55987S |
| UM | UNIT |
| UNSPSC | 41116113 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | +4C |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |