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Genscript GDNF, Mouse
Genscript GDNF, Mouse - GSCRPT (Additional S&H or Hazmat Fees May Apply)
List Price
$195.00
Your Price
$195.00
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| NETA PART: | GSCRPT-Z03170-25 |
| MFG.PART: | Z03170-25 |
| UNSPSC: | 12350000 |
| Manufacturer: | GenScript USA Inc |
Product Introduction
| Species | Mouse | |
| Protein Construction |
| |
| Purity | > 95% as analyzed by SDS-PAGE > 95% as analyzed by HPLC | |
| Endotoxin Level | < 0.2 EU/μg of protein by gel clotting method | |
| Biological Activity | ED50 < 8.0 μg/ml, measured in a bioassay using C6 cells. | |
| Expression System | CHO | |
| Apparent Molecular Weight | 17~22 kDa, on SDS-PAGE under reducing conditions. | |
| Formulation | Lyophilized after extensive dialysis against PBS. | |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. | |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background
| Target Background | Glial-Derived Neurotrophic Factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-beta family. It is expressed in both central nervous system (CNS) and non-CNS tissues. GDNF signals through a receptor system composed of a RET and one of the four GFR alpha receptors. It promotes the survival and differentiation of dopaminergic neurons, and increases their high-affinity dopamine uptake. In a mouse Parkinson’s Disease model, GDNF has been shown to improve bradykinesia, rigidity, and postural instability. GDNF has also been shown to regulate kidney development, spermatogenesis and affect alcohol consumption. |
| Synonyms | Glial-Derived Neurotrophic Facto; ATF-1; ATF2; HFB1-GDNF; HSCR3 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
| SKU | GSCRPT-Z03170-25 |
|---|---|
| Supplier Part Number | Z03170-25 |
| UM | EA |
| UNSPSC | 12350000 |
| Manufacturer | GenScript USA Inc |
| ProductLine | GSCRPT |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 7 Business Days |
| Hazardous | N |