Miltenyi Biotec Anti-Tcrγ/ -Pe

Miltenyi Biotec 11F2 recognizes the human γ/ T cell receptor (TCR). The T cell receptor is a heterodimeric glycoprotein associated with the CD3 antigen. The TCR consists of a a and a B chain (TCRa/B) or a γ and a chain (TCRγ/ ). Clone 11F2 reacts with a framework epitope of the γ/ T cell–receptor. The γ and TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. The γ chain forms either disulfide-linked or non-disulfide-linked heterodimers with the -subunit. The γ/ T cell–receptor is present on a subset of T lymphocytes in peripheral blood, intestinal epithelium, lymph node, thymus, and spleen. TCR γ/ is involved in the recognition of certain bacterial, self-CD1 molecule, and tumor antigens bound to MHC class I. Γ/ T cells are mainly CD4 negative and CD8 negative. T cells expressing the γ/ TCR have been shown to play a role in oral tolerance, innate immune response for some tumor cells, and autoimmune disease. Antigen presentation by γ/ T cells has been reported. - MLTY (Additional S&H or Hazmat Fees May Apply)