We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Revvity PCSK9 (human) LANCE Ultra TR-FRET Detection Kit
Revvity PCSK9 (human) LANCE Ultra TR-FRET Detection Kit, 10,000 Assay Points - PEMSD (Additional S&H or Hazmat Fees May Apply)
List Price
$15,010.00
Your Price
$15,010.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | PEMSD-TRF1270M |
MFG.PART: | TRF1270M |
UNSPSC: | 41105331 |
Manufacturer: | Revvity |
Revvity The LANCE Ultra Human PCSK9 Detection Kit is designed for detection and quantitation of human PCSK9 in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay. No-wash steps, no separation steps TR-FRET technology Sensitive detection High reproducibility Faster time-to-results Easy automation 96-well, 384-well, and 1536-well formats LANCE and LANCE (Lanthanide chelate excite) Ultra are our TR-FRET (time-resolved fluorescence resonance energy transfer), homogeneous (no wash) technologies. One antibody of interest is labeled with a donor fluorophore (a LANCE Europium chelate) and the second molecule is labeled with an acceptor fluorophore (ULight dye). Upon excitation at 320 or 340 nm, energy can be transferred from the donor Europium chelate to the acceptor fluorophore if sufficiently close for FRET (10 nm). This results in the emission of light at 665 nm. Human Proprotein Convertase Subtilisin / Kexin Type 9 (PCSK9) belongs to the proteinase K subfamily of the secretory subtilase family. This glycoprotein contains 692 amino acids, including a signal peptide, a prodomain, and a catalytic domain. Initially synthesized as a soluble 74 kDa precursor protein, it is cleaved into 14 kDa and 60 kDa domains, which remain associated. This protein plays a major regulatory role in cholesterol homeostasis and is highly expressed in the kidney, liver, and intestine. PCSK9 binds to the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. Reduced LDLR levels result in decreased metabolism of low-density lipoprotein, which could lead to hypercholesterolemia. Inhibition of PCSK9 function is currently being explored as a means of lowering cholesterol levels. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia. - PEMSD
SKU | PEMSD-TRF1270M |
---|---|
Supplier Part Number | TRF1270M |
UM | UNIT |
UNSPSC | 41105331 |
Manufacturer | Revvity |
Temperature | +2 -> +8 C |
Refrigerated-Frozen | Shipped in Blue Ice |
CountryOfOrigin | US |
ProductLine | PEMSD |
Qty | 10000 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 6 Business Days |
Hazardous | N |
HarmonizationCode | 3822005090 |