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Millipore Anti-Marcks Antibody, Clone 2f12 Detects Level Of Marcks & Has Been Published & Validated For Use In Ip & Wb. - Mill (Additional S&H or Hazmat Fees May Apply)
Anti-MARCKS Antibody, clone 2F12 detects level of MARCKS & has been published & validated for use in IP & WB.
Key Applications
Immunoprecipitation
Western Blotting
Biological Information
Immunogen
Purified recombinant human MARCKS; Epitope mapped to the carboxyl-terminal.
Clone
2F12
Host
Mouse
Specificity
MARCKS
Isotype
IgG1
Species Reactivity
Bovine
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NM_002356
Entrez Gene Summary
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
Gene Symbol
MARCKS
80K-L
MACS
PRKCSL
FLJ14368
phosphomyristin
MRACKS
PKCSL
FLJ90045
Purification Method
Ascites
UniProt Number
P29966
UniProt Summary
FUNCTION: SwissProt: P29966 # MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. SIZE: 332 amino acids; 31555 Da PTM: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity. SIMILARITY: SwissProt: P29966 ## Belongs to the MARCKS family.
Molecular Weight
none given
Product Usage Statements
Quality Assurance
routinely evaluated by immunoblot on bovine brain extract
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
