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Millipore Anti-Tissue Factor Antibody, Clone Gma-320 Detects Level Of Tissue Factor & Has Been Published & Validated For Use In Elisa & Wb. - Mill (Additional S&H or Hazmat Fees May Apply)
Anti-Tissue Factor Antibody, clone GMA-320 detects level of Tissue Factor & has been published & validated for use in ELISA & WB.
Key Applications
ELISA
Western Blotting
Biological Information
Immunogen
Purified human tissue factor
Clone
GMA-320
Host
Mouse
Specificity
tissue factor
Isotype
IgG2a
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NM_001993
Entrez Gene Summary
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described.
Gene Symbol
F3
TF
Thromboplastin
TFA
CD142
Purification Method
DEAE purified
UniProt Number
P13726
UniProt Summary
FUNCTION: SwissProt: P13726 # Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. SIZE: 295 amino acids; 33068 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SIMILARITY: SwissProt: P13726 ## Belongs to the tissue factor family.
Molecular Weight
Mr 33kDa
Product Usage Statements
Quality Assurance
routinely evaluated by immunoblot on human tissue factor
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
