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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M | IP, WB | Rb | Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | 07-337 |
| Brand Family | Upstate |
| Trade Name |
|
| Description | Anti-SOS1 Antibody, CT |
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | Protein A purified Rabbit Ig in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-SOS1 Antibody, CT is an antibody against SOS1 for use in IP & WB. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | peptide corresponding to amino acids 1243-1258 (KKSDHGNAFFPNSPSP) of murine Son of Sevenless Homolog 1 Protein (SOS 1) |
| Host | Rabbit |
| Specificity | SOS1 |
| Isotype | IgG |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. |
| Gene Symbol |
|
| Purification Method | Protein A chromatography |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: Q07889 # Promotes the exchange of Ras-bound GDP by GTP. SIZE: 1333 amino acids; 152464 Da SUBUNIT: Interacts with GRB2. Interacts with phosphorylated LAT2. TISSUE SPECIFICITY: Expressed in gingival tissues. DISEASE: SwissProt: Q07889 # Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also designated GINGF1. Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva. GGF1 is usually transmitted as an autosomal dominant trait, although sporadic cases are common. & Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS4 is associated with juvenile myelomonocytic leukemia (JMML). SOS1 mutations engender a high prevalence of pulmonary valve disease; atrial septal defects are less common. SIMILARITY: SwissProt: Q07889 ## Contains 1 DH (DBL-homology) domain. & Contains 1 N-terminal Ras-GEF domain. & Contains 1 PH domain. & Contains 1 Ras-GEF domain. |
| Molecular Weight | 175 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | routinely evaluated by immunoblot on 3T3/A31, A431 cell lysates, or HeLa nuclear extracts |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 200 µg |