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Millipore Anti-Vav3 Antibody, Human Detects Level Of Vav3 & Has Been Published & Validated For Use In Ip, Wb, Ic, Ih. - Mill (Additional S&H or Hazmat Fees May Apply)
0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%
Quality Level
MQ100
Applications
Application
Anti-Vav3 Antibody, human detects level of Vav3 & has been published & validated for use in IP, WB, IC, IH.
Key Applications
Immunoprecipitation
Western Blotting
Immunocytochemistry
Immunohistochemistry
Biological Information
Immunogen
KLH-conjugated, synthetic peptide corresponding to amino acids 566-591of human Vav3.
Host
Rabbit
Specificity
Vav3
Isotype
IgG
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_006113
Entrez Gene Summary
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene Symbol
VAV3
FLJ40431
Purification Method
Protein A Purfied
UniProt Number
Q9UKW4
UniProt Summary
FUNCTION: SwissProt: Q9UKW4 # Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. SIZE: 847 amino acids; 97776 Da SUBUNIT: Interacts with the PH domain of APS. SIMILARITY: SwissProt: Q9UKW4 ## Contains 1 CH (calponin-homology) domain. & Contains 1 DH (DBL-homology) domain. & Contains 1 PH domain. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 SH2 domain. & Contains 2 SH3 domains.
Molecular Weight
98 kDa
Product Usage Statements
Quality Assurance
routinely evaluated by immunoblot in RIPA lysates from HeLa and Jurkat cells
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
