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Also known as Vitamin D(3) 24-hydroxylase, CYP24A1 is a member of the cytochrome P450 (CYP) family of enzymes. Most members of the CYP family can metabolize multiple substrates, and can catalyze multiple reactions. The CYP24A1 is a mitochondrial protein that starts the breakdown of 1,25-dihydrozyvitamin D3 by hydroxylation of the side chain to form calcitroic acid. This enzyme also has a role in calcium homeostasis and the vitamin D endocrine system.
Product Information
Format
Affinity Purified
Control
A549 cell lysate
Presentation
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-CYP24A1 Antibody is an antibody against CYP24A1 for use in 0.
Key Applications
Western Blotting
Immunohistochemistry
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human CYP24A1.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Species Reactivity
Human
Species Reactivity Note
Demonstrated to react with Human. Other Homologies: Bovine (92% sequence homology) and Rat (75% sequence homology).
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_000773
Gene Symbol
CYP24A1
CYP24
Purification Method
Affinity Purfied
UniProt Number
Q07973
Molecular Weight
~60 kDa observed. Two isoforms are known to exist at 59 kDa and 51 kDa. This antibody is expected to recognize both isoforms.
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in A549 cell lysate.
Western Blot Analysis: 0.2 µg/mL of this antibody detected CYP24A1 in 10 µg of A549 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
