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Genscript IL-1RA, Human
Genscript IL-1RA, Human - GSCRPT (Additional S&H or Hazmat Fees May Apply)
List Price
$1,245.00
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$1,245.00
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| NETA PART: | GSCRPT-Z00367-1 |
| MFG.PART: | Z00367-1 |
| UNSPSC: | 41105300 |
| Manufacturer: | GenScript USA Inc |
Product Introduction
| Species | Human | |
| Protein Construction |
| |
| Purity | > 95% as analyzed by SDS-PAGE | |
| Endotoxin Level | < 1 EU/μg of protein by LAL method | |
| Biological Activity | Measured by its ability to inhibit IL-1 beta induced NF-kB signaling in 293-IL1 Res cells. The ED50 for this effect is 13.2 ng/mL. | |
| Expression System | E. coli | |
| Theoretical Molecular Weight | 17.3 kDa | |
| N-terminal Sequence Analysis | The sequence of the first five N-terminal amino acids was determined and found to be Met-Arg-Pro-Ser-Gly. | |
| Apparent Molecular Weight | ~18 kDa, on SDS-PAGE under non-reducing conditions. | |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. | |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. | |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
Background
| Target Background | Interleukin-1 receptor antagonist (IL-1ra) is a member of the IL-1 family. Endogenous IL-1ra is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-ra. The regulated expression of IL1ra in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1ra is markedly enhanced by IL-1, TNF-alpha, or PDGF. |
| Synonyms | IL-1ra; IL1 Receptor Antagonist; Interleukin-1 Receptor Antagonist; Interleukin1 Receptor Antagonist |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
| SKU | GSCRPT-Z00367-1 |
|---|---|
| Supplier Part Number | Z00367-1 |
| UM | EA |
| UNSPSC | 41105300 |
| Manufacturer | GenScript USA Inc |
| ProductLine | GSCRPT |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 7 Business Days |