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Genscript PDGF-BB, Human
Genscript PDGF-BB, Human - GSCRPT (Additional S&H or Hazmat Fees May Apply)
List Price
$2,870.00
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$2,870.00
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| NETA PART: | GSCRPT-Z02892-1 |
| MFG.PART: | Z02892-1 |
| UNSPSC: | 41105300 |
| Manufacturer: | GenScript USA Inc |
Product Introduction
| Species | Human | |
| Protein Construction | Expressed with an N-terminal Met.
| |
| Purity | > 97% as analyzed by SDS-PAGE > 97% as analyzed by HPLC | |
| Endotoxin Level | < 1 EU/μg of protein by LAL method | |
| Biological Activity | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 3.0 ng/ml, corresponding to a specific activity of > 3.3 × 105 IU/mg. | |
| Expression System | E. coli | |
| Theoretical Molecular Weight | 24.8 kDa | |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4. | |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. | |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
Background
| Target Background | Platelet-Derived Growth Factor-BB (PDGF-BB) is one of five dimers (PDGF-AA, AB, BB, CC, and DD) formed by 4 different PDGF subunits. In vivo, PDGF-BB is mainly produced in heart and placenta, and predominantly expressed by osteoblasts, fibroblasts, smooth muscle cells, and glial cells. An inactive precursor of PDGF-BB is produced in the endoplasmic reticulum and then activated by a proprotein convertase after secretion. PDGF-BB functions in a paracrine manner and promotes organogenesis, human skeletal development, and wound healing. PDGF-BB also promotes angiogenesis, particularly in the presence of Fibroblast Growth Factor basic. Therefore, PDGF-BB and its related pathways are potential pharmacological targets. |
| Synonyms | PDGFBB; IBGC5; PDGF-2; PDGF2; SIS; SSV; c-sis; platelet derived growth factor subunit B |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
| SKU | GSCRPT-Z02892-1 |
|---|---|
| Supplier Part Number | Z02892-1 |
| UM | EA |
| UNSPSC | 41105300 |
| Manufacturer | GenScript USA Inc |
| ProductLine | GSCRPT |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 7 Business Days |
| Hazardous | N |