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Genscript sTRAIL R-2/TNFRSF10B, Human
Genscript sTRAIL R-2/TNFRSF10B, Human - GSCRPT (Additional S&H or Hazmat Fees May Apply)
List Price
$1,140.00
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$1,140.00
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NETA PART: | GSCRPT-Z02934-1 |
MFG.PART: | Z02934-1 |
UNSPSC: | 41105300 |
Manufacturer: | GenScript USA Inc |
Product Introduction
Species | Human | |
Protein Construction |
| |
Purity | > 97% as analyzed by SDS-PAGE > 97% as analyzed by HPLC | |
Endotoxin Level | < 1 EU/μg of protein by LAL method | |
Biological Activity | Fully biologically active when compared to standard. rHusTRAIL-R2 reduced the production of LPS-induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10 ng/ml) but in the presence of rHusTRAIL-R2, TRAIL-induced TNF is suppressed. | |
Expression System | E. coli | |
Theoretical Molecular Weight | 14.8 kDa | |
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4. | |
Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. | |
Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
Background
Target Background | Tumor necrosis factor-related apoptosis-inducing ligand Receptor 2 (TRAIL-R2) is a cell-surface receptor involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell-death signaling.1 The death ligand TRAIL bears high potential as a new anticancer agent, as binding to the death receptors TRAIL-R1 or TRAIL-R2 triggers apoptosis in most cancer cells.2 TRAIL-R2 has been shown to be associated with a decrease in the survival rates of breast cancer patients. |
Synonyms | Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; TRICKB; TRICK2A; TRICK2B; KILLER/DR5 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
SKU | GSCRPT-Z02934-1 |
---|---|
Supplier Part Number | Z02934-1 |
UM | EA |
UNSPSC | 41105300 |
Manufacturer | GenScript USA Inc |
ProductLine | GSCRPT |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 7 Business Days |
Hazardous | N |