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Genscript HB-EGF, Human
Genscript HB-EGF, Human - GSCRPT (Additional S&H or Hazmat Fees May Apply)
List Price
$815.00
Your Price
$815.00
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NETA PART: | GSCRPT-Z03142-1 |
MFG.PART: | Z03142-1 |
UNSPSC: | 41105300 |
Manufacturer: | GenScript USA Inc |
Product Introduction
Species | Human | |
Protein Construction |
| |
Purity | > 95% as analyzed by SDS-PAGE > 95% as analyzed by HPLC | |
Endotoxin Level | < 0.2 EU/μg of protein by gel clotting method | |
Biological Activity | ED50 < 0.5 ng/ml, measured in a cell proliferation assay using 3T3 cells. | |
Expression System | CHO | |
Theoretical Molecular Weight | 9.7 kDa | |
Apparent Molecular Weight | 12~14 kDa, on SDS-PAGE under reducing conditions. | |
Formulation | Lyophilized after extensive dialysis against PBS. | |
Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. | |
Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background
Target Background | Proheparin-binding EGF-like growth factor (HB-EGF), also known as DTR, DTS and HEGFL, is a member of the EGF family of mitogens. It is expressed in macrophages, monocytes, endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. Compared to EGF, HB-EGF binds to the EGF receptor with a higher affinity and has been shown to bemore mitogenic, likely due to its ability to bind to heparin and heparin sulfate proteoglycans. HB-EGF has also been reported to act as a diphtheria toxin receptor, mediating endocytosis of the bound toxin. Heparin-binding EGF-like growth factor has been shown to interact with NRD1, Zinc finger and BTB domain-containing protein 16 and BAG1. |
Synonyms | HEGFL; Heparin Binding EGF-like growth factor; HBEGF; Diphtheria toxin receptor; DTR |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
SKU | GSCRPT-Z03142-1 |
---|---|
Supplier Part Number | Z03142-1 |
UM | EA |
UNSPSC | 41105300 |
Manufacturer | GenScript USA Inc |
ProductLine | GSCRPT |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 7 Business Days |
Hazardous | N |