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Genscript sIL-6Rα, His, Human
Genscript sIL-6Rα, His, Human - GSCRPT (Additional S&H or Hazmat Fees May Apply)
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$1,625.00
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$1,625.00
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| NETA PART: | GSCRPT-Z03213-1 |
| MFG.PART: | Z03213-1 |
| UNSPSC: | 41105300 |
| Manufacturer: | GenScript USA Inc |
Product Introduction
| Species | Human | ||||
| Protein Construction | Expressed with an N-terminal Met.
| ||||
| Purity | > 95% as analyzed by SDS-PAGE > 95% as analyzed by HPLC | ||||
| Endotoxin Level | < 0.2 EU/μg of protein by gel clotting method | ||||
| Biological Activity | ED50 < 50.0 ng/ml, measured by the cytotoxicity assay using M1 cells in presence of 10.0 ng/ml of human IL-6, corresponding to a specific activity of > 2.0 × 104 units/mg. | ||||
| Expression System | Sf9 insect cells | ||||
| Apparent Molecular Weight | ~50 kDa, on SDS-PAGE under reducing conditions. | ||||
| Formulation | Lyophilized after extensive dialysis against PBS. | ||||
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml. | ||||
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background
| Target Background | Interleukin-6 Receptor (IL-6R) is a single trans-membrane protein that is the receptor for Interleukin-6 (IL-6). IL-6R forms a hexameric complex upon binding 2 molecules of IL-6 and two molecules of glycoprotein 130 (gp130) which activates intracellular JAK/STAT pathways. Although the normal form of IL-6R is the membrane-bound 80 kDa subunit, a soluble form of IL-6R (sIL-6R) can be generated physiologically by limited proteolysis or alternative splicing. sIL-6R binds to both IL-6 and gp130 generating intracellular signaling. In the immune system, sIL-6R is produced by both naïve and memory CD4 T-cells and strongly augments IL-6 ligand’s induction of Th-17 cells. |
| Synonyms | Interleukin-6 receptor subunit alpha; IL-6R subunit alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80; CD_antigen: CD126; sIL6RA |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
| SKU | GSCRPT-Z03213-1 |
|---|---|
| Supplier Part Number | Z03213-1 |
| UM | EA |
| UNSPSC | 41105300 |
| Manufacturer | GenScript USA Inc |
| ProductLine | GSCRPT |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 7 Business Days |
| Hazardous | N |