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Cell Signaling Toll-Like Receptor 4 (D8l5w) Rabbit mAb (Mouse Specific)
Cell Signaling Toll-Like Receptor 4 (D8l5w) Rabbit mAb (Mouse Specific) - CSIG (Additional S&H or Hazmat Fees May Apply)
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$327.00
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$327.00
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NETA PART: | CSIG-14358S |
MFG.PART: | 14358S |
UNSPSC: | 41116124 |
Manufacturer: | Cell Signaling |
Size | 100 µl |
Reactivity | M |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 100-135 |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Western Blotting: 1:1000} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20ºC. Do not aliquot the antibody. |
Specificity/Sensitivity | Toll-like Receptor 4 (D8L5W) Rabbit mAb recognizes endogenous levels of total Toll-like receptor 4 protein. |
Species Reactivity | Mouse |
Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant mouse Toll-like receptor 4 protein. |
Background | Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-4). TLRs recognize conserved motifs found in various pathogens and mediate defense responses (5-7). Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes (4). The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the Toll/Interleukin-1 receptor (TIR) domain (1). Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains, including myeloid differentiation factor 88 (MyD88), MyD88-adaptor-like/TIR-associated protein (MAL/TIRAP), Toll-receptor-associated activator of interferon (TRIF), and Toll-receptor-associated molecule (TRAM) (8-10). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK (8,11-14). Activation of IKK leads to the degradation of IκB, which normally maintains NF-κB in an inactive state by sequestering it in the cytoplasm.TLR4 functions in association with MD-2 in the recognition and initiation of immune responses elicited by lipopolysaccharide (LPS) of Gram-negative bacteria (4-8). TLR4 triggers the activation of NF-κB, IRF-3, and MAPK pathways leading to the production of inflammatory cytokines (9). |
SKU | CSIG-14358S |
---|---|
Supplier Part Number | 14358S |
UM | UNIT |
UNSPSC | 41116124 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |