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Cell Signaling Cxcl10 (D5l5l) Rabbit mAb
Cell Signaling Cxcl10 (D5l5l) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$327.00
Your Price
$327.00
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NETA PART: | CSIG-14969S |
MFG.PART: | 14969S |
UNSPSC: | 41116124 |
Manufacturer: | Cell Signaling |
Size | 100 µl |
Reactivity | H |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 10 |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Western Blotting: 1:1000} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | CXCL10 (D5L5L) Rabbit mAb recognizes endogenous levels of total CXCL10 protein. This antibody also cross-reacts with a 100kDa protein of unknown orgin in some cell lines. |
Species Reactivity | Human |
Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human CXCL10 protein. |
Background | Chemokine (C-X-C motif) ligand 10 (CXCL10, IP-10) is a chemokine produced by a number of cell types and that is induced in response to pro-inflammatory cytokines, such as IFN-γ and TNF-α (1,2). CXCL10 binds to the chemokine receptor CXCR3 and induces calcium flux and cell migration (3). The CXCR3 protein is normally expressed on activated CD4+ T cells and NK cells, which can produce pro-inflammatory cytokines, including IFN-γ and TNF-α (3,4). As a result, these molecules act in an amplification loop to promote immune responses in the contexts of both autoimmunity and a tumor immune response (5,6). |
SKU | CSIG-14969S |
---|---|
Supplier Part Number | 14969S |
UM | UNIT |
UNSPSC | 41116124 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |