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Cell Signaling Aml1 (D33g6) Xp Rabbit mAb (Pe Conjugate)
Cell Signaling Aml1 (D33g6) Xp Rabbit mAb (Pe Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$435.00
Your Price
$435.00
HOW MUCH YOU SAVE:
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NETA PART: | CSIG-15002S |
MFG.PART: | 15002S |
UNSPSC: | 41116124 |
Manufacturer: | Cell Signaling |
Size | 100 µl (50 tests) |
Reactivity | H Mk |
Sensitivity | Endogenous |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Flow Cytometry (Fixed/Permeabilized): 1:50} |
Storage | Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibodies. Protect from light. Do not freeze. |
Specificity/Sensitivity | AML1 (D33G6) XP® Rabbit mAb (PE Conjugate) recognizes endogenous levels of total AML1 protein. |
Species Reactivity | Human, Monkey |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to amino acids at the amino terminus of human AML1 protein. |
Background | AML1 (also known as Runx1, CBFA2, and PEBP2αB) is a member of the core binding factor (CBF) family of transcription factors (1,2). It is required for normal development of all hematopoietic lineages (3-5). AML1 forms a heterodimeric DNA binding complex with its partner protein CBFβ and regulates the expression of cellular genes by binding to promoter and enhancer elements. AML1 is commonly translocated in hematopoietic cancers: chromosomal translocations include t(8;21) AML1-ETO, t(12;21) TEL-AML, and t(8;21) AML-M2 (6). Phosphorylation of AML1 on several potential serine and threonine sites, including Ser249, is thought to occur in an Erk-dependent manner (7,8). |
SKU | CSIG-15002S |
---|---|
Supplier Part Number | 15002S |
UM | UNIT |
UNSPSC | 41116124 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | +4C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |