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Cell Signaling Foxp3 (D2w8e) Rabbit mAb (Ihc Specific)
Cell Signaling Foxp3 (D2w8e) Rabbit mAb (Ihc Specific) - CSIG (Additional S&H or Hazmat Fees May Apply)
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$343.00
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| NETA PART: | CSIG-98377S |
| MFG.PART: | 98377S |
| UNSPSC: | 41116124 |
| Manufacturer: | Cell Signaling |
| Size | 100 µl |
| Reactivity | H Mk |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 45 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {IHC Leica Bond: 1:50, Immunohistochemistry (Paraffin): 1:50 - 1:200} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #74816. |
| Specificity/Sensitivity | FoxP3 (D2W8E™) Rabbit mAb recognizes endogenous levels of total FoxP3 protein. |
| Species Reactivity | Human, Monkey |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human FoxP3. |
| Background | Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors containing a sequence known as Forkhead box or winged helix DNA binding domain (1). The human genome contains 43 Fox proteins that are divided into subfamilies. The FoxP subfamily has four members, FoxP1 - FoxP4, which are broadly expressed and play important roles in organ development, immune response, and cancer pathogenesis (2-4). The FoxP subfamily has several characteristics that are atypical among Fox proteins: their Forkhead domain is located at the carboxy-terminal region and they contain motifs that promote homo- and heterodimerization. FoxP proteins usually function as transcriptional repressors (4,5).FoxP3 is crucial for the development of T cells with regulatory properties (Treg) (6). Mutations in FoxP3 are associated with immune dysregulation, polyendocrinopathy, enteropathy, and X-linked syndrome (IPEX) (7), while overexpression in mice causes severe immunodeficiency (8). Research studies have shown that FoxP3 functions as a tumor suppressor in several types of cancer (9-11). |
| SKU | CSIG-98377S |
|---|---|
| Supplier Part Number | 98377S |
| UM | UNIT |
| UNSPSC | 41116124 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | -20C |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |