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Genscript TGF-B1, Human
Genscript TGF-B1, Human - GSCRPT (Additional S&H or Hazmat Fees May Apply)
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$3,339.00
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$3,339.00
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NETA PART: | GSCRPT-Z03411-1 |
MFG.PART: | Z03411-1 |
UNSPSC: | 41116127 |
Manufacturer: | GenScript USA Inc |
Product Introduction
Species | Human | |
Protein Construction |
| |
Purity | > 95% as analyzed by SDS-PAGE | |
Endotoxin Level | < 0.2 EU/μg of protein by gel clotting method | |
Biological Activity | ED50 < 0.2 ng/ml, measured in ability to inhibit the mouse IL-4-dependent proliferation of HT-2 cells. | |
Expression System | CHO | |
Apparent Molecular Weight | ~12 kDa, on SDS-PAGE under reducing conditions. | |
Formulation | Lyophilized from a 0.2 μm filtered solution in 50 mM NaAc, 50 mM NaCl, pH 5.0. | |
Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or 50 mM Citrate up to 100 μg/ml. | |
Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background
Target Background | TGF-β1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-β1 superfamily that share a characteristic cystine knot structure. TGF-β1, -2 and -3 are highly pleiotropic cytokines that act as cellular switches to regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Each TGF-β isoform has some non-redundant function; for TGF-β1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation and died of overwhelming inflammation. TGF-β1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF-β RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF-β RI (also called activin receptor‑like kinase (ALK)-5), or alternatively, ALK-1. This complex phosphorylates and activates Smad proteins that regulate transcription. |
Synonyms | TGF-beta-1; CED; DPD1; TGFB; TGF-b1; TGFB1; CEDLAP; latency-associated peptide; TGF beta; TGF-beta 1 protein; transforming growth factor beta-1 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
SKU | GSCRPT-Z03411-1 |
---|---|
Supplier Part Number | Z03411-1 |
UM | EA |
UNSPSC | 41116127 |
Manufacturer | GenScript USA Inc |
ProductLine | GSCRPT |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 7 Business Days |
Hazardous | N |