We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Genscript B7-2/CD86 Fc Chimera, Human
Genscript B7-2/CD86 Fc Chimera, Human - GSCRPT (Additional S&H or Hazmat Fees May Apply)
List Price
$1,200.00
Your Price
$1,200.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | GSCRPT-Z03416-1 |
MFG.PART: | Z03416-1 |
UNSPSC: | 41116127 |
Manufacturer: | GenScript USA Inc |
Product Introduction
Species | Human | ||||
Protein Construction |
| ||||
Purity | > 95% as analyzed by SDS-PAGE | ||||
Endotoxin Level | < 0.2 EU/μg of protein by gel clotting method | ||||
Biological Activity | Immobilized B7-2/CD86, hFc, Human at 5.0 μg/ml (100 µl/well) can bind human Biotin-CD28-Fc. | ||||
Expression System | HEK 293 | ||||
Apparent Molecular Weight | 65~80 kDa, on SDS-PAGE under reducing conditions. | ||||
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS, 5% trehalose and mannitol. | ||||
Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. | ||||
Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background
Target Background | B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs), both are type 1 transmembrane proteins with a membrane distal IgV and a membrane proximal IgC domain. They share ~25% sequence homology and interact with the same receptors, CD28 and CTLA-4.Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. T cell activation requires engagement of the T cell receptor (TCR) with the peptide–MHC complex presented on the cell surface of antigen presenting cells (APCs). In addition to this antigen-specific interaction, a second interaction involving costimulatory receptors (CD28, ICOS) on T cells and their respective ligands (B7-1/B7-2, ICOS-L) on APCs is required for optimal T cell activation. B7-1 and B7-2 may also function to deliver signal into dendritic cells. While B7-1 favors binding to CTLA-4, B7-2 shows a preference for CD28. |
Synonyms | Activation B7-2 antigen; B70; B7-2 antigen; B72; B7-2; B-lymphocyte activation antigen B7-2; BU63; CD28 antigen ligand 2; CD86; B7-2; CD28LG2; LAB72; MGC34413 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
SKU | GSCRPT-Z03416-1 |
---|---|
Supplier Part Number | Z03416-1 |
UM | EA |
UNSPSC | 41116127 |
Manufacturer | GenScript USA Inc |
ProductLine | GSCRPT |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 7 Business Days |
Hazardous | N |