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Cell Signaling Lipin 1 (D2w9g) Rabbit mAb
Cell Signaling Lipin 1 (D2w9g) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$327.00
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$327.00
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NETA PART: | CSIG-14906S |
MFG.PART: | 14906S |
UNSPSC: | 12352300 |
Manufacturer: | Cell Signaling |
Size | 100 µl |
Reactivity | H M |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 130 |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:100, Immunofluorescence (Immunocytochemistry): 1:800} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | Lipin 1 (D2W9G) Rabbit mAb recognizes endogenous levels of total lipin 1 protein. This antibody may also cross-react with an unidentified protein of 35 kDa. |
Species Reactivity | Human, Mouse |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human lipin 1 protein. |
Background | Lipin 1 was identified as a nuclear protein required for adipose tissue development (1). The expression of Lipin 1 is induced during adipocyte differentiation (1). The abnormal development of adipose tissues caused by mutations in the lipin 1 gene results in lipodystrophy, a condition associated with low body fat, fatty liver, hypertriglyceridemia, and insulin resistance (1). Lipin 1 plays a role in lipid metabolism in various tissues and cell types including liver, muscle, adipose tissues, and neuronal cell lines (2-4). It has dual functions at the molecular level: Lipin 1 serves as a transcriptional coactivator in liver, and a phosphatidate phosphatase in triglyceride and phospholipid biosynthesis pathways (5). Lipin 1 is regulated by mTOR, illustrating a connection between adipocyte development and nutrient-sensing pathways (6). It also mediates hepatic insulin signaling by TORC2/CRTC2 (7). |
SKU | CSIG-14906S |
---|---|
Supplier Part Number | 14906S |
UM | UNIT |
UNSPSC | 12352300 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |