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Millipore Active, N-Terminal 6his-Tagged, Recombinant, Human Sik, Amino Acids 1-281. For Use In Kinase Assays. - Mill (Additional S&H or Hazmat Fees May Apply)
N-terminal 6His-tagged, recombinant, human SIK, amino acids 1-281.
Product Information
Quality Level
MQ100
Applications
Application
Active, N-terminal 6His-tagged, recombinant, human SIK, amino acids 1-281. For use in Kinase Assays.
Key Applications
Kinase Assay
Biological Information
Source
Expressed by baculovirus in Sf21 insect cells.
Specific Activity
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
NM_173354.3
Gene Symbol
SNF1LK
MSK
msk
SIK
SIK1
Protein Target
SIK
Purification Method
Ni2+/NTA-agarose
Target Sub-Family
CAMK
UniProt Number
P57059
UniProt Summary
FUNCTION: SwissProt: P57059 # Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3 (By similarity). COFACTOR: Magnesium. SIZE: 783 amino acids; 84902 Da SUBUNIT: Binds to and is activated by YWHAZ when phosphorylated on Thr-182. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: SwissProt: P57059 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. & Contains 1 protein kinase domain. & Contains 1 UBA domain.
Molecular Weight
36.2kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by phosphorylation of AMARA Substrate Peptide (Catalog# 12-557).
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 6 months at -70°C from date of shipment
