Millipore Anti-Phospho-Ilk (Ser246) Rabbit Ab, 100ug

Millipore Anti-phospho-ILK (Ser246) Rabbit Antibody, 100 ug Net Content, 1 mg/mL, Polyclonal, Phosphorylated Ser246 Epitope, Rabbit Host Species, Affinity Purified, Liquid Form, 7.4 pH, 2 to 8 deg C, Phosphorylation Modification, KLH Conjugate, Human, Mouse, Ox, Rat Species Reactivity. ILK (Integrin-Linked Kinase) is an intraceullar Ser/Thr kinase with four Ankyrin-like repeats. It is known to play pivotal roles in extracellular matrix mediated signaling. ILK is known to associate with β-Integrins in addition to many other focal adhesion associated proteins. In this context, ILK is involved cell adhesion and migration. The kinase activity appears to be reduced following integrin activation and overexpression of p59 ILK inhibits cellular adhesion to integrin substrates. Additionally, ILK has been associated with epithelial mesechymal transition (EMT) in a TGF-β1 induced Smad dependent manner (Li, 2003). Forced expression of ILK also induced the expression of MMP-2 (matrix metalloprotease 2) and promoted cell migration and invasion (Li, 2003) (Additional S&H or Hazmat Fees May Apply) - Mill