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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M | WB, IH(P) | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | ABN200 |
| Description | Anti-C-X-C chemokine receptor type 5 (CXCR5) Antibody |
| Alternate Names |
|
| Background Information | C-X-C chemokine receptor type 5 (CXCR5; Burkitt lymphoma receptor 1; Monocyte-derived receptor 15) is a G-protein coupled cytokine receptor that binds selectively to the CXCL13 (B lymphocyte chemoattractant) ligand, and mediates the development and function of the immune system. It is expressed in mature B cells, and facilitates the migration of B cells into follicles of the splenic white pulp, and enables deposition of antigen on follicular dendritic cells. It is also involved in the development of lymph nodes and Peyer’s patches. Previous studies have reported that the expression of CXCR5 increases in rheumatoid arthritis. |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Control |
|
| Presentation | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-C-X-C chemokine receptor type 5 (CXCR5) Antibody is an antibody against C-X-C chemokine receptor type 5 (CXCR5) for use in Western Blotting, IHC(P). |
| Key Applications |
|
| Application Notes | Immunohistochemistry Analysis: A 1:1,000 dilution from representative lot detected C-X-C chemokine receptor type 5 (CXCR5) in mouse frontal cortex neurons and mouse spleen lymphocytes. |
| Biological Information | |
|---|---|
| Immunogen | KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human C-X-C chemokine receptor type 5 (CXCR5). |
| Epitope | Cytoplasmic domain |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Specificity | This antibody recognizes the cytoplasmic domain of C-X-C chemokine receptor type 5 (CXCR5). |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Gene Symbol |
|
| Purification Method | Affinity Purfied |
| UniProt Number |
|
| Molecular Weight | ~51 / 38 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing with molecular weights ~42 and ~37 kDa. The calculated molecular weight of this protein is 42 kDa, but can be observed at ~51 kDa due to high glycosylation. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blot in SH-SY5Y cell lysate. Western Blot Analysis: 0.1 µg/mL of this antibody detected C-X-C chemokine receptor type 5 (CXCR5) in 10 µg of SH-SY5Y cell lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |