Miltenyi Biotec Cd11a Antibody, Anti-Human, Apc-Vio 770, Reafini

Miltenyi Biotec Clone REA378 recognizes the human CD11a antigen, a single-pass type I membrane protein also known as integrin a-L (ITGAL). Integrins are heterodimeric adhesion molecules comprised of a- and B-subunits that participate in immune cell interactions as well as in immune cell-extracellular matrix interactions. CD11a combines with CD18 (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 is a receptor for CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), and CD242 (ICAM-4). It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T cell–mediated killing, and antibody dependent killing by granulocytes and monocytes. Interactions between LFA-1 and CD54 (ICAM-1) play a critical role in T cell–B cell collaboration. | Additional information: Clone REA378 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)