Miltenyi Biotec Cd144 (Ve-Cadherin) Antibody, Anti-Human, Apc-Vio

Miltenyi Biotec Clone REA199 recognizes CD144 (VE-Cadherin), a 120 KDa type II cadherin. Cadherins are cell adhesion molecules and mediate Ca 2)+ dependent homophilic interactions. CD144 contains five extracellular cadherin (EC) domains and like other cadherins can interact directly via its C-terminus with cytoplasmic proteins such as B-catenin, plaktoglobin, and p120. Plaktoglobin und B-catenin bind to a-catenin, which in turn interacts with several actin-binding proteins, a-actinin, ajuba, zonula occludens-1 (ZO-1). Further indirect interactions of CD144 with partners such as SHP-2, VEGFR-2, Csk, and PAR-3, 6 allows CD144 to not only regulate the stability and strength of cell adhesion but also to serve functions such as sensing of shear forces, anti-proliferative, and anti-apoptotic effects. | Additional information: Clone REA199 displays negligible binding to Fc receptors. | - MLTY (Additional S&H or Hazmat Fees May Apply)