Miltenyi Biotec Cd166 Antibody, Anti-Mouse, Pe, Reafinity

Miltenyi Biotec Clone REA370 recognizes the mouse CD166 antigen, a Single-pass type I membrane protein also known as Activated leukocyte cell adhesion molecule (ALCAM). CD166 is a member of the immunoglobulin gene superfamily which is expressed by activated leukocytes and thymic epithelial cells and is a ligand for the lymphocyte antigen CD6. It is also expressed at high levels in the brain and lung, at lower levels in the liver and the kidney, and on a number of cell lines. CD166 expression is pathologically correlated with aggressive disease in a variety of cancers including melanoma, prostate, breast, ovarian, esophageal, and bladder cancers. It is also a universal functional marker of murine and human hematopoietic stem cells (HSC) and osteoblasts within the hematopoietic niche and it is involved in modulating HSC-niche interactions and HSC fate. | Additional information: Clone REA370 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)