Miltenyi Biotec Cd49d Antibody, Anti-Human, Pe-Vio 770

Miltenyi Biotec CD49d, also known as the a4 integrin chain or VLA-4a chain, is a 150 kDa cell adhesion protein that is directly involved in mononuclear leukocyte trafficking. Dimerized with B7 integrin, the resulting a4B7 integrin binds VCAM-1 (CD106), MAdCAM-1, and fibronectin to facilitate the rolling of leukocytes along vascular epithelium. In T cells, on ligation of MAdCAM-1, a4B7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling. | CD49d is expressed on most mononuclear leukocytes, both in circulation or in lymphoid or other tissues, as well as on eosinophils and basophils. - MLTY (Additional S&H or Hazmat Fees May Apply)