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Miltenyi Biotec Il-12r B2 Antibody, Anti-Mouse, Apc-Vio 770, Rea
Miltenyi Biotec Il-12r B2 Antibody, Anti-Mouse, Apc-Vio 770, Reafinity - MLTY (Additional S&H or Hazmat Fees May Apply)
List Price
$181.50
Your Price
$181.50
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | MLTY-130-125-861 |
MFG.PART: | 130-125-861 |
UNSPSC: | 12352203 |
Manufacturer: | Miltenyi Biotec |
Miltenyi Biotec Clone REA200 recognizes the mouse Interleukin-12 receptor subunit beta-2 (IL-12R B2) antigen, a Single-pass type I membrane protein which forms the functional high affinity IL-12 receptor together with the IL-12R B1 subunit. While the IL-12R B1 subunit is constitutively expressed, the expression of the IL-12R B2 gene is up-regulated by interferon gamma. IL-12R B2 is expressed by Th1 cells and IL-12 signaling through the IL-12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL-12R B2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. The up-regulation of IL-12R B2 is found to be associated with a number of infectious diseases, such as Crohns disease and leprosy, which is thought to contribute to the inflammatory response and host defense. | Additional information: Clone REA200 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)
SKU | MLTY-130-125-861 |
---|---|
Supplier Part Number | 130-125-861 |
UM | EA |
UNSPSC | 12352203 |
Manufacturer | Miltenyi Biotec |
MSDS URL | https://www.miltenyibiotec.com/ds/130-125-861 |
ProductLine | MLTY |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |
Hazardous | N |