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Miltenyi Biotec Cd223 Antibody, Anti-Human, Pe-Vio 770, Reafinit
Miltenyi Biotec Cd223 Antibody, Anti-Human, Pe-Vio 770, Reafinity - MLTY (Additional S&H or Hazmat Fees May Apply)
List Price
$170.50
Your Price
$170.50
HOW MUCH YOU SAVE:
0.00 %
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NETA PART: | MLTY-130-127-931 |
MFG.PART: | 130-127-931 |
UNSPSC: | 12352203 |
Manufacturer: | Miltenyi Biotec |
Miltenyi Biotec Clone REA351 recognizes the human CD223 antigen, a single-pass type I membrane protein also known as lymphocyte activation gene 3 protein (LAG-3). CD223 is a CD4 homolog with four extracellular Ig superfamily domains. Similar to CD4, CD223 oligomerizes at the surfaces of T cells and binds to MHC II on antigen presenting cells but with significantly higher affinity than CD4. CD223 is expressed on activated CD4+ and CD8+ T lymphocytes where it associates with the CD3–TCR complex at the cell surface and negatively regulates signal transduction. As a consequence, it negatively regulates T cell proliferation, function, and homeostasis. There is also increasing evidence of its involvement in regulatory function of tumor-infiltrated T cells in cancer, such as in Hodgkin’s lymphomas and in prostate cancer. CD223 is also expressed on activated NK cells, B cells, and plasmacytoid dendritic cells. | Additional information: Clone REA351 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)
SKU | MLTY-130-127-931 |
---|---|
Supplier Part Number | 130-127-931 |
UM | EA |
UNSPSC | 12352203 |
Manufacturer | Miltenyi Biotec |
MSDS URL | https://www.miltenyibiotec.com/ds/130-127-931 |
ProductLine | MLTY |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |
Hazardous | N |