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Cell Signaling Rgs4 (D4v1p) Rabbit mAb
Cell Signaling Rgs4 (D4v1p) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$327.00
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$327.00
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| NETA PART: | CSIG-15129S |
| MFG.PART: | 15129S |
| UNSPSC: | 12352200 |
| Manufacturer: | Cell Signaling |
| Size | 100 µl |
| Reactivity | H M R |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 25 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | RGS4 (D4V1P) Rabbit mAb recognizes endogenous levels of total RGS4 protein. |
| Species Reactivity | Human, Mouse, Rat |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human RGS4 protein. |
| Background | Regulators of G protein signaling (RGS) are a family of about 40 proteins that determine the signaling amplitude and duration of G protein-coupled receptor signaling via modulation of the GTPase activity of G proteins (1-3). Each RGS has a distinct structure, expression pattern, and regulation, resulting in preferential interactions with receptors, G proteins, and other signaling proteins, as well as a unique function (4).Regulator of G-protein signaling 4 (RGS4) is a small RGS (23 kDa) that belongs to the R4 subfamily of heterotrimeric G-protein regulators. RGS4 contains a short amino-terminus that may be responsible for its functional specificity towards G-protein-coupled receptors, and a conserved RGS domain responsible for GAP activity (1). The RGS4 protein shares activity at both Gαq and Gαi/o proteins (5,6). Degradation of RGS4 is regulated by opioid receptor-mediated ubiquitination following stimulation by opioid receptor agonists, such as the DAMGO synthetic opioid peptide (7). RGS4 modulates the action of morphine and other opiates in vivo (8). |
| SKU | CSIG-15129S |
|---|---|
| Supplier Part Number | 15129S |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | -20C |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |