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Cayman Gfap (Human, Recombinant); Purity- Greater Than Or Equal T
NETA PART: | CAYM-27353-100 |
MFG.PART: | 27353-100 |
UNSPSC: | 12352202 |
Manufacturer: | Cayman |
Product Description
Glial fibrillary acidic protein (GFAP) is a protein encoded by the GFAP gene in humans and a member of the class III intermediate filament (IF) protein family. It is composed of an N-terminal head domain, a highly conserved α-helical rod domain, and a C-terminal tail domain that mediate GFAP self-assembly, dimerization, and oligomerization, respectively., GFAP is expressed in, and has commonly been used as a pan marker for, mature astrocytes. GFAP IFs form a dynamic network of cytosolic filament proteins that collectively provide structure and strength to the cytoskeleton of astrocytes, thus supporting their morphology and function. Isolated astrocytes from neonatal Gfap-/- mouse brain have reduced numbers of IFs and IF bundles, increased proliferation, and loss of contact-inhibited growth., Gfap-/- mice develop more diffuse and infiltrative brain lesions compared to wild-type littermates in a mouse model of experimental autoimmune encephalomyelitis (EAE). Mutations in the rod and tail domains of GFAP have been associated with Rosenthal fiber formation, a hallmark of Alexander disease. Transgenic overexpression of Gfap in mice increases the expression of certain cytokines and antioxidative enzymes in the olfactory bulb and has been used as a mouse model of Alexander disease. GFAP can be citrullinated on the arginine residue at position 270 (R270) and at R416 by protein arginine deiminase 1 (PAD1; Item No. ) and PAD2 (Item No. ). Citrullinated GFAP has been found in rat cerebral cortex in a model of traumatic brain injury, as well as in postmortem hippocampus from patients with Alzheimers disease.,
WARNING This product is not for human or veterinary use.
Technical Information
- ALXDRD
- Glial Fibrillary Acidic Protein, Intermediate Filament Protein
Shipping & Storage Information
SKU | CAYM-27353-100 |
---|---|
Supplier Part Number | 27353-100 |
UM | EA |
UNSPSC | 12352202 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/27353m.pdf |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |