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Cayman Citrullinated Gfap (Human, Recombinant); Purity- Greater T
NETA PART: | CAYM-28622-100 |
MFG.PART: | 28622-100 |
UNSPSC: | 12352202 |
Manufacturer: | Cayman |
Product Description
Citrullinated glial fibrillary acidic protein (citGFAP) is a citrullinated form of GFAP (Item No. ), a class III intermediate filament (IF) protein that is expressed in mature astrocytes and contributes to cytoskeletal structure and strength. GFAP can be citrullinated in a calcium-dependent manner on the arginine residue at position 270 (R270) and at R416 by protein arginine deiminase 1 (PAD1; Item No. ) and PAD2 (Item No. ). citGFAP levels are increased by the calcium ionophore ionomycin (Item No. ) in an in vitro model of traumatic brain injury (TBI) using NHA CC-2565 human astrocytes and are induced by controlled cortical impact in the cerebral cortex in a rat model of TBI. It has been found in the hippocampus in a rat model of Alzheimers disease induced by amyloid-β (25-35), as well as in the retina in a mouse model of alkali-induced eye injury., citGFAP has also been found in postmortem hippocampus from patients with Alzheimers disease, and citGFAP levels are increased in postmortem-derived brain lesions from patients with multiple sclerosis., Caymans Citrullinated GFAP protein can be used for Western blot and ELISA applications.
WARNING This product is not for human or veterinary use.
Technical Information
- ALXDRD
- Glial Fibrillary Acidic Protein, Intermediate Filament Protein
Shipping & Storage Information
SKU | CAYM-28622-100 |
---|---|
Supplier Part Number | 28622-100 |
UM | EA |
UNSPSC | 12352202 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/28622m.pdf |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |