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GenScript DM1 AB (15L2), mAb, Mouse
GenScript The product is specific for DM1 and DM1 structurally similar molecules - GSCRPT (Additional S&H or Hazmat Fees May Apply)
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$160.00
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$160.00
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| NETA PART: | GSCRPT-A02223-40 |
| MFG.PART: | A02223-40 |
| UNSPSC: | 12352202 |
| Manufacturer: | GenScript USA Inc |
Overview
| Specificity | The product is specific for DM1 and DM1 structurally similar molecules. |
| Host Species | Mouse |
| Immunogen | DM1-KLH |
| Conjugate | Unconjugated |
Applications
| Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product. | |||||||||
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Properties
| Form | Liquid |
| Storage Buffer | Supplied in PBS, pH 7.4, containing 0.02% ProClin300. |
| Concentration | 0.5 mg/mL |
| Storage Instructions | The product remains stable up to 1 year at -20 °C from date of receipt. Avoid repeated freezing and thawing cycles. |
| Purification | Protein A affinity column |
| Isotype | Mouse IgG1, κ |
| Clonality | Monoclonal |
| Clone ID | 15L2 |
| Note | GenScript can customize this product per customers request including product size, buffer components, etc. |
Background
| Target Background | Payloads are the important components of antibody-drug conjugates (ADCs). The most commonly used ADC payloads are MMAE, DM1, and DXd. ADC pharmacokinetic (PK) studies include free payload analysis, conjugated antibody analysis, and total antibody analysis via ligand-binding assay (LBA) and LC-MS/MS assay. The anti-payload antibody is a useful reagent in PK assay for determining conjugated antibodies. It can be used as a capture antibody to determine the conjugated antibody in LBA assay or through immunocapture to enrich the ADC sample in LC-MS/MS assay. The DM1, also known as mertansine, is a microtubule polymerization inhibitor. Trastuzumab emtansine (T-DM1), composed of trastuzumab conjugated to DM1, is a type of targeted cancer drug for breast cancer treatment. T-DM1 is targeted toward HER2 (ERBB2) positive breast cancer. |
| Synonyms | Mertansine, Maytansinoid DM1, DM 1, 139504-50-0 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
| SKU | GSCRPT-A02223-40 |
|---|---|
| Supplier Part Number | A02223-40 |
| UM | EA |
| UNSPSC | 12352202 |
| Manufacturer | GenScript USA Inc |
| ProductLine | GSCRPT |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 7 Business Days |