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Genscript TIGIT, His, Human
Genscript TIGIT, His, Human - GSCRPT (Additional S&H or Hazmat Fees May Apply)
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$1,500.00
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$1,500.00
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NETA PART: | GSCRPT-Z03457-1 |
MFG.PART: | Z03457-1 |
UNSPSC: | 12352202 |
Manufacturer: | GenScript USA Inc |
Product Introduction
Species | Human | ||||
Protein Construction |
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Purity | > 90% as analyzed by SDS-PAGE | ||||
Endotoxin Level | < 1 EU/μg of protein by gel clotting method | ||||
Biological Activity | This proten can bind with CHO-K1/aAPC/CD155 Clone by FACS analysis. | ||||
Expression System | HEK 293+J15 | ||||
Apparent Molecular Weight | ~16.0 kDa, on SDS-PAGE under reducing conditions. | ||||
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. | ||||
Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. | ||||
Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background
Target Background | T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an immune receptor present on some T cells and natural killer cells (NK). This protein could bind to CD155 (PVR) with high affinity, which causes increased secretion of IL-10 and decreased secretion of IL-12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. TIGIT could also bind to CD112 (PVRL2) with lower affinity. TIGITs inhibition of NK cytotoxicity can be blocked by antibodies against its interaction with PVR and the activity is directed through its ITIM domain. |
Synonyms | VSIG9, VSTM3, WUCAM, T-cell immunoreceptor with Ig and ITIM domains, T cell immunoreceptor with Ig and ITIM domains |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
SKU | GSCRPT-Z03457-1 |
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Supplier Part Number | Z03457-1 |
UM | EA |
UNSPSC | 12352202 |
Manufacturer | GenScript USA Inc |
ProductLine | GSCRPT |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 7 Business Days |
Hazardous | N |