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Genscript VEGF-R2 Fc Chimera, Mouse
Genscript VEGF-R2 Fc Chimera, Mouse - GSCRPT (Additional S&H or Hazmat Fees May Apply)
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$1,200.00
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$1,200.00
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NETA PART: | GSCRPT-Z03555-1 |
MFG.PART: | Z03555-1 |
UNSPSC: | 12352202 |
Manufacturer: | GenScript USA Inc |
Product Introduction
Species | Mouse | ||||
Protein Construction |
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Purity | > 95% as analyzed by SDS-PAGE | ||||
Endotoxin Level | < 1 EU/μg of protein by gel clotting method | ||||
Biological Activity | Immobilized Mouse VEGF164 at 2.0 μg/ml (100 μl/well) can bind VEGF-R2, hFc, Mouse with EC50=96.15 ng/ml when detected by Mouse Anti Human IgG Fc-HRP. | ||||
Expression System | HEK 293 | ||||
Apparent Molecular Weight | ~153.5 kDa, on SDS-PAGE under reducing conditions. | ||||
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. | ||||
Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. | ||||
Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background
Target Background | VEGF-R2 belongs to a family of proteins called receptor tyrosine kinases. The receptor has three main parts: one part extends out of the cell and binds to VEGF, another spans the cell’s membrane, while the third part is found inside the cell. The current model of VEGF-R2 activation is that VEGF binds to individual VEGF-R2 receptor proteins on the membrane, and brings two of them close enough to form a complex called a dimer. The receptor dimer is activated and initiates signaling within the cell. VEGF-R2 is a receptor tyrosine kinase (RTK) which transduces biochemical signals via lateral dimerization in the plasma membrane. Like most RTKs, VEGF-R2 is composed of an extracellular (EC) domain, a transmembrane (TM) domain, and an intracellular (IC) domain consisting of a kinase domain and sequences required for downstream signaling. The EC domain consists of seven immunoglobulin homology (Ig) domains, termed D1 (at the N-terminus) to D7 (closest to the membrane). VEGF-R2 binds to, and is activated by the ligands VEGF-A, VEGF-E, and a number of processed forms of VEGF-C and VEGF-D. Ligand binding to VEGF-R2 is mediated by Ig-domains 2 and 3 and the linker between D2 and D3. |
Synonyms | KDR, CD309, FLK1, VEGFR, VEGFR2 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
SKU | GSCRPT-Z03555-1 |
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Supplier Part Number | Z03555-1 |
UM | EA |
UNSPSC | 12352202 |
Manufacturer | GenScript USA Inc |
ProductLine | GSCRPT |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 7 Business Days |
Hazardous | N |