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Cell Signaling Dck Antibody
Cell Signaling Dck Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$302.00
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$302.00
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NETA PART: | CSIG-10478S |
MFG.PART: | 10478S |
UNSPSC: | 12352203 |
Manufacturer: | Cell Signaling |
Size | 100 µl |
Reactivity | H M |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 29 |
Source/Isotype | Rabbit |
Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | dCK Antibody recognizes endogenous levels of total dCK protein. This antibody detects a doublet of unknown origin at approximately 80 kDa by western blot. |
Species Reactivity | Human, Mouse |
Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val250 of human dCK protein. Antibodies are purified by peptide affinity chromatography. |
Background | Deoxycytidine kinase (dCK) catalyzes the rate-limiting step in the nucleoside salvage pathway. dCK phosphorylates salvaged deoxycytidine (dC) to generate deoxycytidine monophosphate (dCMP), a precursor for both dCTP and dTTP pools (1). dCK also phosphorylates deoxyadenosine (dA) and deoxyguanosine (dG) to generate deoxyadenosine monophosphate and deoxyguanosine monophosphate, respectively. Gemcitabine is an anticancer nucleoside that is a dC analog. It is a pro-drug and must be phosphorylated by dCK to an active form. dCK is phosphorylated on Ser74 by the DNA damage signaling kinases ATM and ATR, and this phosphorylation increases dCK activity (2,3). |
SKU | CSIG-10478S |
---|---|
Supplier Part Number | 10478S |
UM | EA |
UNSPSC | 12352203 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
CountryOfOrigin | US |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |
Hazardous | N |