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Cell Signaling Serpinb1 (E4w7b) Rabbit mAb
Cell Signaling Serpinb1 (E4w7b) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
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$386.00
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$386.00
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| NETA PART: | CSIG-20407S |
| MFG.PART: | 20407S |
| UNSPSC: | 12352203 |
| Manufacturer: | Cell Signaling |
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 42 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunohistochemistry (Paraffin): 1:50 - 1:200} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | SerpinB1 (E4W7B) Rabbit mAb recognizes endogenous levels of total SerpinB1 protein. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu264 of human SerpinB1 protein. |
| Background | Serpin family B member 1 (SerpinB1), also known as leukocyte elastase inhibitor or neutrophil elastase inhibitor, regulates inflammation and the innate immune response. SerpinB1 blocks the activity of caspase-1, caspase-4, and caspase-5; the protein does so via suppression of caspase recruitment domain oligomerization and enzymatic activation (1). SerpinB1 is expressed in neutrophils and monocytes, and the protein resides in the cytoplasm due to its lack of a secretory signal sequence (2,3). There, SerpinB1 protects cells from serine proteases that may leak from granules into the cytoplasm, including Cathepsin G, neutrophil elastase, proteinase-3, and Granzyme H (4,5). Despite its lack of a secretory sequence, SerpinB1 was shown to be released from keratinocytes in a caspase-1-dependent manner to upregulate proliferation of pancreatic β cells (6). |
| SKU | CSIG-20407S |
|---|---|
| Supplier Part Number | 20407S |
| UM | each |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | -20C |
| CountryOfOrigin | US |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |
| Hazardous | N |