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Cell Signaling Nr2f6/Ear-2 (E7q7g) Rabbit mAb
Cell Signaling Nr2f6/Ear-2 (E7q7g) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$364.00
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$364.00
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| NETA PART: | CSIG-24847S |
| MFG.PART: | 24847S |
| UNSPSC: | 12352203 |
| Manufacturer: | Cell Signaling |
| Size | 100 µl |
| Reactivity | H M |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 43 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:200} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | NR2F6/EAR-2 (E7Q7G) Rabbit mAb recognizes endogenous levels of total NR2F6/EAR-2 protein. |
| Species Reactivity | Human, Mouse |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human NR2F6/EAR-2 protein. |
| Background | NR2F6 (Nuclear receptor subfamily 2 group F member 6, EAR-2, COUP-TFIII) is a member of the NR2F family of transcription factors, defined by their role in the regulation of organogenesis, neurogenesis, and cellular differentiation during embryonic development (1,3). NR2F6 acts as a negative regulator for TRβ1-mediated transcriptional activity, a transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells, and a repressor of the NFAT/AP-1 complex on both the interleukin-2 and the interferon-γ cytokine promoters (2-5). NR2F6 has a non-redundant role in antagonizing anti-cancer effector T cell responses (5). It has been shown that loss of NR2F6 enhances the activity of established PD-L1 checkpoint blockade, promoting tumor regression and increased survival in mouse models (5,6). |
| SKU | CSIG-24847S |
|---|---|
| Supplier Part Number | 24847S |
| UM | each |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | -20C |
| CountryOfOrigin | US |
| ProductLine | CSIG |
| Qty | 1 each |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |
| Hazardous | N |