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Cell Signaling Serpinb9 (E9x9z) Rabbit mAb (Alexa Fluor 647 Conjugate)
Cell Signaling Serpinb9 (E9x9z) Rabbit mAb (Alexa Fluor 647 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$435.00
Your Price
$435.00
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NETA PART: | CSIG-37232S |
MFG.PART: | 37232S |
UNSPSC: | 12352203 |
Manufacturer: | Cell Signaling |
Size | 100 µl (50 tests) |
Reactivity | H |
Sensitivity | Endogenous |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Flow Cytometry (Fixed/Permeabilized): 1:50} |
Storage | Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. |
Specificity/Sensitivity | SERPINB9 (E9X9Z) Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of total SERPINB9 protein. |
Species Reactivity | Human |
Source/Purification | Monoclonal antibody is produced by immunizing animals with human SERPINB9 recombinant protein and reacts with an epitope surrounding Met280. |
Background | SERPINB9 (Sb9, PI-9) is a member of the serpin superfamily of proteins which bind to and inactivate serine proteinases (1,2). SERPINB9 is present in human CD4+ T cells, CD8+ T cells, NK cells, B cells, and myeloid cells, and is a physiological inhibitor of Granzyme B (GrB) (1,3,4). Granzyme B triggers apoptosis when released by cytotoxic T lymphocytes (1-4). SERPINB9 may function to protect effector and bystander cells from Granzyme B during an immune response (4). In mice, SPI6 is thought to be the functional homolog of SERPINB9 due to its inhibition of murine Granzyme B (2,5). SERPINB9 was recently identified as a potential immunotherapy target, due to its role in tumor cell survival through evasion of apoptosis (6). |
SKU | CSIG-37232S |
---|---|
Supplier Part Number | 37232S |
UM | EA |
UNSPSC | 12352203 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | +4C |
CountryOfOrigin | US |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |
Hazardous | N |