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Cell Signaling G4s Linker (E7o2v) Rabbit mAb (Alexa Fluor ® 700 Conjugate)
Cell Signaling G4s Linker (E7o2v) Rabbit mAb (Alexa Fluor ® 700 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$463.00
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$463.00
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| NETA PART: | CSIG-40107S |
| MFG.PART: | 40107S |
| UNSPSC: | 12352203 |
| Manufacturer: | Cell Signaling |
| Size | 100 µl (50 tests) |
| Reactivity | All |
| Sensitivity | Transfected Only |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Flow Cytometry (Live): 1:50} |
| Storage | Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. |
| Specificity/Sensitivity | G4S Linker (E7O2V) Rabbit mAb (Alexa Fluor® 700 Conjugate) recognizes exogenously expressed levels of scFv-based CARs containing a G4S linker. |
| Species Reactivity | All Species Expected |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide containing three Gly4Ser repeats. |
| Background | The poly-Glycine-Serine (G4S) linker is a type of flexible, unstructured synthetic peptide linker sequence often leveraged to connect the variable heavy (VH) domain and variable light (VL) domain of single-chain variable fragments (scFvs) and chimeric antigen receptors (CARs) that utilize an extracellular domain scFv for target antigen recognition. The linker itself consists of a core pentapeptide sequence, Gly-Gly-Gly-Gly-Ser, that is repeated and commonly found as either a 15-mer (G4S)3 or 20-mer (G4S)4 within scFv-based CARs and scFv fragments. The linker sequence length plays a role in controlling scFv stability and the noncovalent association between the VH and VL domains (1,2). |
| SKU | CSIG-40107S |
|---|---|
| Supplier Part Number | 40107S |
| UM | each |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | +4C |
| CountryOfOrigin | US |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |
| Hazardous | N |