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Cell Signaling Hsp20 (E6o7a) Xp ® Rabbit mAb
Cell Signaling Hsp20 (E6o7a) Xp ® Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$152.00
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$152.00
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NETA PART: | CSIG-55091T |
MFG.PART: | 55091T |
UNSPSC: | 12352203 |
Manufacturer: | Cell Signaling |
Size | 20 µl |
Reactivity | H R |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 17 |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Western Blotting: 1:1000, Immunohistochemistry (Paraffin): 1:50 - 1:200, Immunofluorescence (Immunocytochemistry): 1:200 - 1:800} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | HSP20 (E6O7A) XP® Rabbit mAb recognizes endogenous levels of total HSP20 protein. |
Species Reactivity | Human, Rat |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro25 of human HSP20 protein. |
Background | The small heat shock protein 20 (HSP20/HSPB6) is a ubiquitously expressed molecular chaperone, with higher levels found in skeletal, cardiac, and smooth muscle (1). HSP20 plays a cardioprotective role in response to injury through cardiac β-adrenergic signaling, which induces increased HSP20 protein expression and phosphorylation at Ser16 by PKA (2-4). Phosphorylation of HSP20 at Ser16 protects cells from undergoing apoptosis (5) and mediates HSP20 interaction with the cytoskeleton (6). Constitutive phosphorylation of HSP20 at Ser16 in mice leads to fibrosis and heart failure through interleukin-6 (IL-6) and STAT3 signaling (7). |
SKU | CSIG-55091T |
---|---|
Supplier Part Number | 55091T |
UM | EA |
UNSPSC | 12352203 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |
Hazardous | N |