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Cell Signaling Parvalbumin (E8n2u) Xp Rabbit mAb
Cell Signaling Parvalbumin (E8n2u) Xp Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
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$152.00
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| NETA PART: | CSIG-80561T |
| MFG.PART: | 80561T |
| UNSPSC: | 12352203 |
| Manufacturer: | Cell Signaling |
| Size | 20 µl |
| Reactivity | H M R |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 12 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50, Immunohistochemistry (Paraffin): 1:50 - 1:200, Immunofluorescence (Frozen): 1:1600} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | Parvalbumin (E8N2U) XP® Rabbit mAb recognizes endogenous levels of total parvalbumin protein. In mouse models, this antibody nonspecifically labels muscle in small intestine and juxtaglomerular cells in kidney by immunofluorescence. |
| Species Reactivity | Human, Mouse, Rat |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human parvalbumin protein. |
| Background | Parvalbumin (PV, PVALB) is a member of the EF-hand family of calcium-binding proteins, containing EF-hand domains with a high affinity for calcium and magnesium (1). Parvalbumin is expressed in both the soma and in processes of specific subclasses of GABAergic interneurons. Parvalbumin is a slow calcium buffer, meaning it accelerates the initial phase of decay of calcium after an action potential, which likely inhibits facilitation and is thought to regulate short-term synaptic plasticity (2,3). Altered function of PV positive interneurons has been implicated in many neurological diseases, such as Alzheimer’s disease, autism spectrum disorder, schizophrenia, and bipolar disorder (4). |
| SKU | CSIG-80561T |
|---|---|
| Supplier Part Number | 80561T |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | -20C |
| CountryOfOrigin | US |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |
| Hazardous | N |