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Cell Signaling Stap2 Antibody
Cell Signaling Stap2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$302.00
Your Price
$302.00
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NETA PART: | CSIG-81007S |
MFG.PART: | 81007S |
UNSPSC: | 12352203 |
Manufacturer: | Cell Signaling |
Size | 100 µl |
Reactivity | H |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 50, 55 |
Source/Isotype | Rabbit |
Application/Dilution | {Western Blotting: 1:1000} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | STAP2 antibody recognizes endogenous levels of total STAP2 protein. |
Species Reactivity | Human |
Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human STAP2 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
Background | STAP2 (signal-transducing adaptor protein 2, BRK substrate, BKS) is an adaptor protein expressed in various tissues and cell lines (1). The protein sequence of STAP2 contains a PH domain, an SH2 like domain, a proline rich region, and a YXXQ motif for interaction with various signaling molecules. (2). In the immune system, STAP2 plays important roles in cytokine signaling, macrophage activation, T cell migration, and motility via interaction with, and regulation of, signaling molecules such as STAT3, STAT5, IKKα/β, CSF1R, VAV, FAK, and Fas ligand. In leukemia, prostate cancer, breast cancer, and melanoma, STAP2 has been shown to promote tumor growth and metastasis via stabilization and activation of signaling molecules, including BCR/ABL, EGFR, BRK, STATs, and tyrosinase (3-6). |
SKU | CSIG-81007S |
---|---|
Supplier Part Number | 81007S |
UM | EA |
UNSPSC | 12352203 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |