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Cell Signaling Phospho-Tyrosine Mouse mAb (P-Tyr-100)
Cell Signaling Phospho-Tyrosine Mouse mAb (P-Tyr-100) - CSIG (Additional S&H or Hazmat Fees May Apply)
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$323.00
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$323.00
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| NETA PART: | CSIG-9411S |
| MFG.PART: | 9411S |
| UNSPSC: | 12352203 |
| Manufacturer: | Cell Signaling |
| Size | 200 µl |
| Reactivity | All |
| Sensitivity | Endogenous |
| Source/Isotype | Mouse IgG1 |
| Application/Dilution | {Western Blotting: 1:2000, Immunoprecipitation: 1:100, Immunohistochemistry (Paraffin): 1:4800, Immunofluorescence (Paraffin): 1:1600, Immunofluorescence (Frozen): 1:1600, Immunofluorescence (Immunocytochemistry): 1:1600, Flow Cytometry (Fixed/Permeabilized): 1:3200, Peptide ELISA (DELFIA): 1:4000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #80379. |
| Specificity/Sensitivity | Phospho-Tyrosine Mouse mAb (P-Tyr-100) is a high affinity antibody. ELISAs against a wide variety of phosphopeptides indicate that P-Tyr-100 binds phospho-Tyr in a manner largely independent of the surrounding amino acid sequence. 2D gel Western blot analysis of pervanadate-treated cell extracts also shows that P-Tyr-100 interacts with a broad range of tyrosine-phosphorylated proteins. P-Tyr-100 does not cross-react with peptides containing phospho-Ser or phospho-Thr. |
| Species Reactivity | All Species Expected |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with phospho-tyrosine containing peptides . |
| Background | Tyrosine phosphorylation plays a key role in cellular signaling (1). Research studies have shown that in cancer, unregulated tyrosine kinase activity can drive malignancy and tumor formation by generating inappropriate proliferation and survival signals (2). Antibodies specific for phospho-tyrosine (3,4) have been invaluable reagents in these studies. The phospho-tyrosine monoclonal antibodies developed by Cell Signaling Technology are exceptionally sensitive tools for studying tyrosine phosphorylation and monitoring tyrosine kinase activity in high throughput drug discovery. |
| SKU | CSIG-9411S |
|---|---|
| Supplier Part Number | 9411S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | -20C |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |
| Hazardous | N |