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Cell Signaling Kctd5 Antibody
Cell Signaling Kctd5 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$302.00
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$302.00
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| NETA PART: | CSIG-94396S |
| MFG.PART: | 94396S |
| UNSPSC: | 12352203 |
| Manufacturer: | Cell Signaling |
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 26 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | KCTD5 Antibody recognizes endogenous levels of total KCTD5 protein. In some cell lines, this antibody also recognizes a 100 kDa band of unknown origin. |
| Species Reactivity | Human |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg38 of human KCTD5 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Background | BTB/POZ domain-containing protein KCTD5 is a member of the potassium channel tetramerization domain family of proteins that play a role in transcriptional repression, cytoskeletal regulation, and ion channel gating (1). KCTD5 interacts with bound ubiquitin proteins and cullin3, and acts as a dependent E3 ligase substrate adaptor through interactions with its BTB domain (2). KCTD5 has been identified as a negative regulator of the AKT pathway by acting as an off switch for G-protein coupled receptor signaling by triggering proteolysis of Gβγ heterodimers dissociated from the Gα subunit (3). |
| SKU | CSIG-94396S |
|---|---|
| Supplier Part Number | 94396S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | -20C |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |